2g63 | pdb_00002g63

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File:2g63.png

Template:STRUCTURE 2g63

Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 24b

Template:ABSTRACT PUBMED 16759095

About this Structure

2g63 is a 4 chain structure of Dipeptidyl peptidase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Pei Z, Li X, Longenecker K, von Geldern TW, Wiedeman PE, Lubben TH, Zinker BA, Stewart K, Ballaron SJ, Stashko MA, Mika AK, Beno DW, Long M, Wells H, Kempf-Grote AJ, Madar DJ, McDermott TS, Bhagavatula L, Fickes MG, Pireh D, Solomon LR, Lake MR, Edalji R, Fry EH, Sham HL, Trevillyan JM. Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors. J Med Chem. 2006 Jun 15;49(12):3520-35. PMID:16759095 doi:10.1021/jm051283e

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