3h3c | pdb_00003h3c

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Template:STRUCTURE 3h3c

File:3h3c.png

Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog

Template:ABSTRACT PUBMED 19428251

About this Structure

3h3c is a 1 chain structure of Focal adhesion kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Walker DP, Zawistoski MP, McGlynn MA, Li JC, Kung DW, Bonnette PC, Baumann A, Buckbinder L, Houser JA, Boer J, Mistry A, Han S, Xing L, Guzman-Perez A. Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3253-8. Epub 2009 Apr 24. PMID:19428251 doi:10.1016/j.bmcl.2009.04.093

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