3iw4 | pdb_00003iw4

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Template:STRUCTURE 3iw4

File:3iw4.png

Crystal structure of PKC alpha in complex with NVP-AEB071

Template:ABSTRACT PUBMED 19827831

About this Structure

3iw4 is a 3 chain structure of Protein kinase C with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A, Cowan-Jacob SW, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S. Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5 -dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes. J Med Chem. 2009 Oct 22;52(20):6193-6. PMID:19827831 doi:10.1021/jm901108b

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