3qlg | pdb_00003qlg

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Template:STRUCTURE 3qlg

File:3qlg.png

Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib

Template:ABSTRACT PUBMED 17355866

About this Structure

3qlg is a 2 chain structure of C-Src tyrosine kinase with sequence from Gallus gallus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Seeliger MA, Nagar B, Frank F, Cao X, Henderson MN, Kuriyan J. c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure. 2007 Mar;15(3):299-311. PMID:17355866 doi:10.1016/j.str.2007.01.015
  2. Dar AC, Lopez MS, Shokat KM. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem Biol. 2008 Oct 20;15(10):1015-22. PMID:18940662 doi:10.1016/j.chembiol.2008.09.007

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