3drr | pdb_00003drr

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File:3drr.png

Template:STRUCTURE 3drr

HIV reverse transcriptase Y181C mutant in complex with inhibitor R8e

Template:ABSTRACT PUBMED 18826204

About this Structure

3drr is a 2 chain structure of Reverse transcriptase with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

See Also

Reference

  1. Tucker TJ, Sisko JT, Tynebor RM, Williams TM, Felock PJ, Flynn JA, Lai MT, Liang Y, McGaughey G, Liu M, Miller M, Moyer G, Munshi V, Perlow-Poehnelt R, Prasad S, Reid JC, Sanchez R, Torrent M, Vacca JP, Wan BL, Yan Y. Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5 -chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses. J Med Chem. 2008 Oct 1. PMID:18826204 doi:10.1021/jm800856c

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