3dga | pdb_00003dga

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File:3dga.png

Template:STRUCTURE 3dga

Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP

Template:ABSTRACT PUBMED 19146480

About this Structure

3dga is a 4 chain structure of Dihydrofolate reductase and Thymidylate synthase with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

See Also

Reference

  1. Dasgupta T, Chitnumsub P, Kamchonwongpaisan S, Maneeruttanarungroj C, Nichols SE, Lyons TM, Tirado-Rives J, Jorgensen WL, Yuthavong Y, Anderson KS. Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. ACS Chem Biol. 2009 Jan 16;4(1):29-40. PMID:19146480 doi:10.1021/cb8002804

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