1dg5 | pdb_00001dg5

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File:1dg5.png

Template:STRUCTURE 1dg5

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND TRIMETHOPRIM

Template:ABSTRACT PUBMED 10623528

About this Structure

1dg5 is a 1 chain structure of Dihydrofolate reductase with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

See Also

Reference

  1. Li R, Sirawaraporn R, Chitnumsub P, Sirawaraporn W, Wooden J, Athappilly F, Turley S, Hol WG. Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J Mol Biol. 2000 Jan 14;295(2):307-23. PMID:10623528 doi:https://dx.doi.org/10.1006/jmbi.1999.3328
  2. Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y. Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol. 2003 May;10(5):357-65. PMID:12704428 doi:10.1038/nsb921

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