2hr6 | pdb_00002hr6

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File:2hr6.png

Template:STRUCTURE 2hr6

Crystal structure of dUTPase in complex with substrate analogue dUDP and manganese

Template:ABSTRACT PUBMED 17932923

About this Structure

2hr6 is a 1 chain structure of Deoxyuridine 5'-triphosphate nucleotidohydrolase with sequence from Escherichia coli. Full crystallographic information is available from OCA.

See Also

Reference

  1. Kovari J, Barabas O, Varga B, Bekesi A, Tolgyesi F, Fidy J, Nagy J, Vertessy BG. Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. Proteins. 2008 Apr;71(1):308-19. PMID:17932923 doi:10.1002/prot.21757
  2. Barabas O, Pongracz V, Kovari J, Wilmanns M, Vertessy BG. Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. J Biol Chem. 2004 Oct 8;279(41):42907-15. Epub 2004 Jun 17. PMID:15208312 doi:10.1074/jbc.M406135200
  3. Gonzalez A, Larsson G, Persson R, Cedergren-Zeppezauer E. Atomic resolution structure of Escherichia coli dUTPase determined ab initio. Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):767-74. Epub 2001, May 25. PMID:11375495

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