Sandbox 31

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Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013.

Adenylate Kinase (PDB ID #: 1ake)

adenylate kinase bound to non-hydrolyzable substrate analogue

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Introduction

Adenylate Kinase is a good little protein.


Physical Properties

Structure

The secondary structure of adenylate kinase shows alpha helicies (cyan) and beta sheets (green) surrounding the non-hydrolyzable substrate analogue (orange). Adenylate kinase has a hydrophilic exterior, and a hydrophobic core, with additional hydrophilic residues on the interior contacting the ligand.

Active Site and Mechanism

residues within 3 angstroms of the ligand are involved in binding the ligand or stabilizing the active site.



References