Sandbox 31

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Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. Adenylate Kinase (PDB ID #: 1ake) spinqualitylabelsall models adenylate kinase bound to non-hydrolyzable substrate analogue Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Introduction Adenylate Kinase is a good little protein. Physical Properties Adenylate kinase is caged with water molecules. Structure The secondary structure of adenylate kinase shows alpha helicies (cyan) and beta sheets (green) surrounding the non-hydrolyzable substrate analogue (orange). Adenylate kinase has a hydrophilic exterior, and a hydrophobic core, with additional hydrophilic residues on the interior contacting the ligand. Active Site and Mechanism residues within 3 angstroms of the ligand are involved in binding the ligand or stabilizing the active site. adenylate kinase's active site is highlighted in dark blue. together you can see that the active site is only a fraction of the molecules involved in binding the ligand. References