StudioG24SecL04Tpc5

	spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D
	Variable Major Protein (VMP)-like sequence Expressed (1l8w), resolution 2.3Å *This representation of VlsE illustrates the only crystal structure available on the PDB site.

VlsE

spinqualitylabelsall models IR6:Immunodominate Region of VlsE Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Structural Overview

VlsE is shown to be composed of four sub-units, each consisting of a variable domain flanked by two invariable domains (Liang). The variable domains themselves contain six variable regions (VR) interspersed amongst six invariable regions (IR). The IRs are embedded deep within the protein covered by alpha helical loops. They are shielded by the VRs.

Additional Links

Antigenic Variation
Lyme Disease

Proteopedia Page Contributors and Editors (what is this?)

Justin Thomas, Tasfik Ahmed, Naveen Pillai, Saad Khamisa