1umx | pdb_00001umx
PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ARG M267 REPLACED WITH LEU (CHAIN M, R267L)
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Overview
Relatively little is known about the functions of specific molecular, interactions between membrane proteins and membrane lipids. The structural, and functional consequences of disrupting a previously identified, interaction between a molecule of the diacidic lipid cardiolipin and the, purple bacterial reaction centre were examined. Mutagenesis of a highly, conserved arginine (M267) that is responsible for binding the head-group, of the cardiolipin (to leucine) did not affect the rate of photosynthetic, growth, the functional properties of the reaction centre, or the X-ray, crystal structure of the complex (determined to a resolution of 2.8 A)., However, the thermal stability of the protein was compromised by this, mutation, part of the reaction centre population showing an approximately, ... [(full description)]
About this Structure
1UMX is a [Protein complex] structure of sequences from [Rhodobacter sphaeroides] with FE, PO4, LDA, BCL, BPB, SPN and U10 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Disruption of a specific molecular interaction with a bound lipid affects the thermal stability of the purple bacterial reaction centre., Fyfe PK, Isaacs NW, Cogdell RJ, Jones MR, Biochim Biophys Acta. 2004 Jan 30;1608(1):11-22. PMID:14741581
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