1j3j | pdb_00001j3j

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Template:STRUCTURE 1j3j

File:1j3j.png

Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP

Template:ABSTRACT PUBMED 12704428

About this Structure

1j3j is a 4 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

See Also

Reference

  1. Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y. Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol. 2003 May;10(5):357-65. PMID:12704428 doi:10.1038/nsb921

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