2iko | pdb_00002iko

Ligands:

7IG

Gene:

REN (Homo sapiens)

Activity:

Renin, with EC number 3.4.23.15

Structural annotation:
Resources:	InterPro : Ipr009007, Ipr001461, Ipr012848, Ipr001969 Pfam : PF00026 UniProt : P00797

Functional annotation:
Cellular component:	extracellular space membrane
Biological process:	regulation of MAPKKK cascade regulation of blood pressure proteolysis angiotensin maturation
Molecular function:	hydrolase activity peptidase activity pepsin A activity renin activity receptor binding aspartic-type endopeptidase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

About this Structure

2iko is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Sarver RW, Peevers J, Cody WL, Ciske FL, Dyer J, Emerson SD, Hagadorn JC, Holsworth DD, Jalaie M, Kaufman M, Mastronardi M, McConnell P, Powell NA, Quin J 3rd, Van Huis CA, Zhang E, Mochalkin I. Binding thermodynamics of substituted diaminopyrimidine renin inhibitors. Anal Biochem. 2007 Jan 1;360(1):30-40. Epub 2006 Oct 30. PMID:17113558 doi:https://dx.doi.org/10.1016/j.ab.2006.10.017