1nnp | pdb_00001nnp
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X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.
Overview
Two X-ray structures of the GluR2 ligand-binding core in complex with (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid ((S)-ATPA) have been determined with and without Zn(2+) ions. (S)-ATPA induces a domain closure of ca. 21 degrees compared to the apo form. The tert-butyl moiety of (S)-ATPA is buried in a partially hydrophobic pocket and forces the ligand into the glutamate-like binding mode. The structures provide new insight into the molecular basis of agonist selectivity between AMPA and kainate receptors.
About this Structure
1NNP is a Single protein structure of sequence from Rattus norvegicus with SO4 and CE2 as ligands. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity., Lunn ML, Hogner A, Stensbol TB, Gouaux E, Egebjerg J, Kastrup JS, J Med Chem. 2003 Feb 27;46(5):872-5. PMID:12593667
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