1opl | pdb_00001opl

Ligands:

MYR, P16

Gene:

Abl (Homo sapiens)

Activity:

Related:

1opj, 1opk

Structural annotation:
Resources:	CATH : 1Opla04, 1Opla03, 1Opla02, 1Opla01 InterPro : Ipr011009, Ipr008266, Ipr015015, Ipr001245, Ipr000980, Ipr000719, Ipr001452 Pfam : PF07714, PF00018, PF00017 SCOP : d1opla3, d1opla2, d1opla1, d1oplb1, d1oplb2 UniProt : P00519

Functional annotation:
Cellular component:	cytoskeleton cytoplasm nucleus
Biological process:	protein amino acid phosphorylation DNA damage response, signal transduction resulting in induction of apoptosis intracellular signaling cascade S-phase-specific transcription in mitotic cell cycle cell adhesion actin cytoskeleton organization and biogenesis mismatch repair regulation of transcription, DNA-dependent peptidyl-tyrosine phosphorylation protein modification process
Molecular function:	transferase activity protein C-terminus binding nucleotide binding kinase activity metal ion binding manganese ion binding magnesium ion binding protein kinase activity ATP binding protein-tyrosine kinase activity DNA binding protein binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

About this Structure

1opl is a 2 chain structure with sequence from Homo sapiens. The July 2003 RCSB PDB Molecule of the Month feature on Src Tyrosine Kinase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2003_7. Full crystallographic information is available from OCA.

Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J. Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell. 2003 Mar 21;112(6):859-71. PMID:12654251