Grb10 SH2 Domain

spinqualitylabelsall models Crystal Structure of the SH2 Domain of Grb10 (PDB entry 1NRV) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Introduction Grb10 is a member of a family of adapter proteins (Grb7 and Grb14) that interacts with tyrosine kinases. Dimerization of the Grb10 SH2 Domain The crystal structure of Grb10 SH2 domain was an important step to understanding how this protein interacts with IGF1 receptors, and although the SH2 domain functions as an independent segment, it forms a dimer in physiological environments. The dimer interface exists due to the intermolecular forces between Phenylalanine515, Tyrosine516, and Asparganine519 of each independent monomer. The structure of Grb10 SH2 forms similar SH2 domains found in other proteins, which have an alpha helix on the outsides with anti-parallel beta sheets. Zoom?

Interaction Between Grb10 and E3 Ubiquitin Ligase NEDD4

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spinqualitylabelsall models Crystal structure of the Nedd4 C2/Grb10 SH2 complex PDB entry 3M7F) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Crystal structure of the NEDD4 C2-GRB10 SH2 complex

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Jason Marks, Michal Harel, Alexander Berchansky