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spinqualitylabelsall models 3ggu Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Description

3ggu is a drug resistant HIV protease. Shown is a patient's variant in complex with darunavir.

HIV proteases are essential for the functioning of the retrovirus that causes AIDS. HIV needs active proteases to process Gag & Gap - Polymerase polyprotein precursors into mature structural proteins and replicative enzymes. HIV proteases contain a highly conserved region Asp - Thr - Gly (Asp25, Thr26 and Gly27), with the aspartic residue beeing the active site in the aspartyl protease.(1)

Contributors

Julia Baaske, Angelika Wackerl