1o79 | pdb_00001o79

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Template:STRUCTURE 1o79

File:1o79.png

STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME

Template:ABSTRACT PUBMED 12747780

About this Structure

1o79 is a 3 chain structure with sequence from Alicyclobacillus acidocaldarius. Full crystallographic information is available from OCA.

Reference

  1. Lenhart A, Reinert DJ, Aebi JD, Dehmlow H, Morand OH, Schulz GE. Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase. J Med Chem. 2003 May 22;46(11):2083-92. PMID:12747780 doi:https://dx.doi.org/10.1021/jm0211218
  2. Lenhart A, Weihofen WA, Pleschke AE, Schulz GE. Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071. Chem Biol. 2002 May;9(5):639-45. PMID:12031670
  3. Wendt KU, Lenhart A, Schulz GE. The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution. J Mol Biol. 1999 Feb 12;286(1):175-87. PMID:9931258 doi:https://dx.doi.org/10.1006/jmbi.1998.2470

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