1z27 | pdb_00001z27
Crystal structure of Native Pvs25, an ookinete protein from Plasmodium vivax.
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Overview
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
About this Structure
1Z27 is a Single protein structure of sequence from Plasmodium vivax. Full crystallographic information is available from OCA.
Reference
The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807
Page seeded by OCA on Thu Feb 21 16:11:23 2008
