7rsa | pdb_00007rsa

Ligands:

DOD, TBU

Activity:

Pancreatic ribonuclease, with EC number 3.1.27.5

Structural annotation:
Resources:	CATH : 7Rsa000 InterPro : Ipr001427 Pfam : PF00074 SCOP : d7rsa__ UniProt : P61824

Functional annotation:
Molecular function:	pancreatic ribonuclease activity endonuclease activity nucleic acid binding hydrolase activity nuclease activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

About this Structure

7rsa is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Wlodawer A, Svensson LA, Sjolin L, Gilliland GL. Structure of phosphate-free ribonuclease A refined at 1.26 A. Biochemistry. 1988 Apr 19;27(8):2705-17. PMID:3401445
Kobe B, Deisenhofer J. Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A. J Mol Biol. 1996 Dec 20;264(5):1028-43. PMID:9000628 doi:https://dx.doi.org/10.1006/jmbi.1996.0694
Richardson JS, Richardson DC. Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2754-9. PMID:11880627 doi:10.1073/pnas.052706099