Met repressor

File:1mjo.png

EcMR (mutant) complex with corepressor SAM and DNA 2eyi

Met repressor (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The corepressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis. For additional details see Joe Granger Methionine Repressor: Escherichia coli.

3D Structures of Met repressor

Updated on 18-March-2013

1cmb – EcMR – Escherichia coli
1mjk – EcMR (mutant)
1cma – EcMR + DNA
1mjm – EcMR (mutant) + DNA
1cmc – EcMR + SAM
1mjl, 1mjp – EcMR (mutant) + SAM
1mj2, 1mjo, 1mjq – EcMR (mutant) + SAM + DNA

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Michal Harel, Alexander Berchansky