2k7l | pdb_00002k7l

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Template:STRUCTURE 2k7l

NMR structure of a complex formed by the C-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1

Template:ABSTRACT PUBMED 19215094

Function

[T2FA_HUMAN] TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.[1]

About this Structure

2k7l is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. Yang A, Abbott KL, Desjardins A, Di Lello P, Omichinski JG, Legault P. NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase. Biochemistry. 2009 Mar 10;48(9):1964-74. PMID:19215094 doi:10.1021/bi801549m
  1. ↑ Rossignol M, Keriel A, Staub A, Egly JM. Kinase activity and phosphorylation of the largest subunit of TFIIF transcription factor. J Biol Chem. 1999 Aug 6;274(32):22387-92. PMID:10428810

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