2jq3 | pdb_00002jq3
From Proteopedia
Structure and Dynamics of Human Apolipoprotein C-III
Template:ABSTRACT PUBMED 18408013
Disease
[APOC3_HUMAN] Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2) [MIM:614028]. HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.[1]
Function
[APOC3_HUMAN] Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
About this Structure
2jq3 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Gangabadage CS, Zdunek J, Tessari M, Nilsson S, Olivecrona G, Wijmenga SS. Structure and dynamics of human apolipoprotein CIII. J Biol Chem. 2008 Jun 20;283(25):17416-27. Epub 2008 Apr 11. PMID:18408013 doi:10.1074/jbc.M800756200
- ↑ von Eckardstein A, Holz H, Sandkamp M, Weng W, Funke H, Assmann G. Apolipoprotein C-III(Lys58----Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. J Clin Invest. 1991 May;87(5):1724-31. PMID:2022742 doi:https://dx.doi.org/10.1172/JCI115190
