2yqk | pdb_00002yqk

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Template:STRUCTURE 2yqk

Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats

Disease

[RERE_HUMAN] Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24).

Function

[RERE_HUMAN] Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.[1]

About this Structure

2yqk is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. ↑ Waerner T, Gardellin P, Pfizenmaier K, Weith A, Kraut N. Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis. Cell Growth Differ. 2001 Apr;12(4):201-10. PMID:11331249

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