3ik5 | pdb_00003ik5
From Proteopedia
SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)
Disease
[CD3Z_HUMAN] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.[1]
Function
[CD3Z_HUMAN] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
About this Structure
3ik5 is a 4 chain structure with sequence from Simian immunodeficiency virus. Full crystallographic information is available from OCA.
Reference
- Kim WM, Sigalov AB, Stern LJ. Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):163-75. Epub 2010 Jan 22. PMID:20124696 doi:10.1107/S090744490904880X
- ↑ Rieux-Laucat F, Hivroz C, Lim A, Mateo V, Pellier I, Selz F, Fischer A, Le Deist F. Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. N Engl J Med. 2006 May 4;354(18):1913-21. PMID:16672702 doi:354/18/1913
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Simian immunodeficiency virus
- Kim, W M.
- Sigalov, A B.
- Stern, L J.
- Cell membrane
- Disulfide bond
- Host-virus interaction
- Lipoprotein
- Membrane
- Myristate
- Phosphoprotein
- Protein-protein complex
- Receptor
- Transmembrane
- Viral immunoevasion
- Viral protein-antiviral protein complex
- Viral protein-signaling protein complex
- Virulence
