1qtt | pdb_00001qtt

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Template:STRUCTURE 1qtt

SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1

Template:ABSTRACT PUBMED 10959629

Disease

[MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.

Function

[MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.[1]

About this Structure

1qtt is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C. Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data. J Biomol NMR. 2000 Jul;17(3):215-30. PMID:10959629
  1. ↑ Laine J, Kunstle G, Obata T, Sha M, Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell. 2000 Aug;6(2):395-407. PMID:10983986

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