3fhc | pdb_00003fhc
Crystal structure of human Dbp5 in complex with Nup214
Disease
[NU214_HUMAN] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
Function
[NU214_HUMAN] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [DD19B_HUMAN] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
About this Structure
3fhc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
Proteopedia Page Contributors and Editors (what is this?)
- Homo sapiens
- Conti, E.
- Moeller, H von.
- Atp-binding
- Beta propeller
- Can
- Ddx19
- Dead-box helicase
- Dead-box protein 19b
- Glycoprotein
- Helicase
- Hydrolase
- Membrane
- Mrna export
- Mrna transport
- Nuclear pore complex
- Nucleoporin
- Nucleotide-binding
- Nucleus
- Phosphoprotein
- Protein transport
- Proto-oncogene
- Reca-like
- Rna dependent atpase
- Rna-binding
- Translocation
- Transport
- Transport protein-hydrolase complex
