2jx3 | pdb_00002jx3
From Proteopedia
NMR solution structure of the N-terminal domain of DEK
Template:ABSTRACT PUBMED 18227428
Disease
[DEK_HUMAN] Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.
Function
[DEK_HUMAN] Involved in chromatin organization.[1]
About this Structure
2jx3 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Devany M, Kappes F, Chen KM, Markovitz DM, Matsuo H. Solution NMR structure of the N-terminal domain of the human DEK protein. Protein Sci. 2008 Feb;17(2):205-15. PMID:18227428 doi:17/2/205
- ↑ Hu HG, Scholten I, Gruss C, Knippers R. The distribution of the DEK protein in mammalian chromatin. Biochem Biophys Res Commun. 2007 Jul 13;358(4):1008-14. Epub 2007 May 21. PMID:17524367 doi:10.1016/j.bbrc.2007.05.019
