2kia | pdb_00002kia
Solution structure of Myosin VI C-terminal cargo-binding domain
Disease
[MYO6_MOUSE] Note=Defects in Myo6 are the cause of Snell's waltzer, a condition characterized by circling, head-tossing, deafness and hyperactivity.
Function
[MYO6_MOUSE] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.
About this Structure
2kia is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.
See Also
Reference
- Yu C, Feng W, Wei Z, Miyanoiri Y, Wen W, Zhao Y, Zhang M. Myosin VI undergoes cargo-mediated dimerization. Cell. 2009 Aug 7;138(3):537-48. PMID:19665975 doi:10.1016/j.cell.2009.05.030
Proteopedia Page Contributors and Editors (what is this?)
- Mus musculus
- Feng, W.
- Miyanoiri, Y.
- Wei, Z.
- Yu, C.
- Zhang, M.
- Actin-binding
- Atp-binding
- Calmodulin-binding
- Cargo-binding domain
- Cell projection
- Coated pit
- Cytoplasmic vesicle
- Deafness
- Disease mutation
- Endocytosis
- Golgi apparatus
- Hearing
- Membrane
- Molecular motor
- Motor protein
- Myosin
- Myosin vi
- Nucleotide-binding
- Nucleus
- Phosphoprotein
- Protein transport
- Transport
