2bb5 | pdb_00002bb5

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Template:STRUCTURE 2bb5

Structure of Human Transcobalamin in complex with Cobalamin

Template:ABSTRACT PUBMED 16537422

Disease

[TCO2_HUMAN] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.

Function

[TCO2_HUMAN] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.

About this Structure

2bb5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Wuerges J, Garau G, Geremia S, Fedosov SN, Petersen TE, Randaccio L. Structural basis for mammalian vitamin B12 transport by transcobalamin. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4386-91. Epub 2006 Mar 14. PMID:16537422

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