2v4z | pdb_00002v4z
From Proteopedia
THE CRYSTAL STRUCTURE OF THE HUMAN G-PROTEIN SUBUNIT ALPHA (GNAI3) IN COMPLEX WITH AN ENGINEERED REGULATOR OF G-PROTEIN SIGNALING TYPE 2 DOMAIN (RGS2)
Function
[RGS2_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.[1][2][3][4]
About this Structure
2v4z is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP. Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). J Biol Chem. 2009 Jul 17;284(29):19402-11. Epub 2009 May 28. PMID:19478087 doi:10.1074/jbc.M109.024711
- ↑ Heximer SP, Lim H, Bernard JL, Blumer KJ. Mechanisms governing subcellular localization and function of human RGS2. J Biol Chem. 2001 Apr 27;276(17):14195-203. Epub 2001 Jan 30. PMID:11278586 doi:10.1074/jbc.M009942200
- ↑ Gu S, Anton A, Salim S, Blumer KJ, Dessauer CW, Heximer SP. Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins. Mol Pharmacol. 2008 Jan;73(1):1-11. Epub 2007 Sep 27. PMID:17901199 doi:10.1124/mol.107.036285
- ↑ Wu HK, Heng HH, Shi XM, Forsdyke DR, Tsui LC, Mak TW, Minden MD, Siderovski DP. Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31. Leukemia. 1995 Aug;9(8):1291-8. PMID:7643615
- ↑ Nguyen CH, Ming H, Zhao P, Hugendubler L, Gros R, Kimball SR, Chidiac P. Translational control by RGS2. J Cell Biol. 2009 Sep 7;186(5):755-65. PMID:19736320 doi:jcb.200811058
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Arrowsmith, C H.
- Bountra, C.
- Edwards, A.
- Knapp, S.
- Pike, A C.W.
- Roos, A K.
- Soundararajan, M.
- Weigelt, J.
- Adp-ribosylation
- Cell cycle
- G-protein coupled receptor
- Gtp hydrolysis
- Gtp-binding
- Guanine nucleotide binding protein
- Lipoprotein
- Myristate
- Nucleotide-binding
- Palmitate
- Phosphoprotein
- Signal transduction inhibitor
- Transducer
- Transmembrane signaling
