1mfl | pdb_00001mfl
From Proteopedia
The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor
Function
[LAP2_HUMAN] Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.[1]
About this Structure
1mfl is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Birrane G, Chung J, Ladias JA. Novel mode of ligand recognition by the Erbin PDZ domain. J Biol Chem. 2003 Jan 17;278(3):1399-402. Epub 2002 Nov 19. PMID:12444095 doi:https://dx.doi.org/10.1074/jbc.C200571200
- ↑ Borg JP, Marchetto S, Le Bivic A, Ollendorff V, Jaulin-Bastard F, Saito H, Fournier E, Adelaide J, Margolis B, Birnbaum D. ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol. 2000 Jul;2(7):407-14. PMID:10878805 doi:10.1038/35017038
