2ftu | pdb_00002ftu

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Template:STRUCTURE 2ftu

solution structure of domain 3 of RAP

Template:ABSTRACT PUBMED 16678114

Disease

[AMRP_HUMAN] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.

Function

[AMRP_HUMAN] Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.

About this Structure

2ftu is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. Lee D, Walsh JD, Mikhailenko I, Yu P, Migliorini M, Wu Y, Krueger S, Curtis JE, Harris B, Lockett S, Blacklow SC, Strickland DK, Wang YX. RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. Mol Cell. 2006 May 5;22(3):423-30. PMID:16678114 doi:10.1016/j.molcel.2006.04.011

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