1b66 | pdb_00001b66

From Proteopedia
Revision as of 04:00, 25 March 2013 by OCA (talk | contribs)
Jump to navigationJump to search

Template:STRUCTURE 1b66

6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE

Template:ABSTRACT PUBMED 10024455

Disease

[PTPS_RAT] Note=Deficiency leads to phenylketonuria.

Function

[PTPS_RAT] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

About this Structure

1b66 is a 2 chain structure with sequence from Rattus rattus. Full crystallographic information is available from OCA.

Reference

  1. Ploom T, Thony B, Yim J, Lee S, Nar H, Leimbacher W, Richardson J, Huber R, Auerbach G. Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase. J Mol Biol. 1999 Feb 26;286(3):851-60. PMID:10024455 doi:10.1006/jmbi.1998.2511
  2. Colloc'h N, Poupon A, Mornon JP. Sequence and structural features of the T-fold, an original tunnelling building unit. Proteins. 2000 May 1;39(2):142-54. PMID:10737935

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1b66&oldid=1759239"