1a4j | pdb_00001a4j

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Template:STRUCTURE 1a4j

DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR

Template:ABSTRACT PUBMED 9506942

Disease

[IGKC_HUMAN] Defects in IGKC are the cause of immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]. IGKCD is a disease characterized by the complete absence of immunoglobulin kappa chains.[1]

About this Structure

1a4j is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. Romesberg FE, Spiller B, Schultz PG, Stevens RC. Immunological origins of binding and catalysis in a Diels-Alderase antibody. Science. 1998 Mar 20;279(5358):1929-33. PMID:9506942
  1. ↑ Stavnezer-Nordgren J, Kekish O, Zegers BJ. Molecular defects in a human immunoglobulin kappa chain deficiency. Science. 1985 Oct 25;230(4724):458-61. PMID:3931219

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