2uxx | pdb_00002uxx
From Proteopedia
Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct
About this Structure
2uxx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Yang M, Culhane JC, Szewczuk LM, Jalili P, Ball HL, Machius M, Cole PA, Yu H. Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry. 2007 Jul 10;46(27):8058-65. Epub 2007 Jun 15. PMID:17569509 doi:10.1021/bi700664y
- Yang M, Gocke CB, Luo X, Borek D, Tomchick DR, Machius M, Otwinowski Z, Yu H. Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell. 2006 Aug 4;23(3):377-87. PMID:16885027 doi:https://dx.doi.org/10.1016/j.molcel.2006.07.012
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Cole, P A.
- Culhane, J C.
- Machius, M.
- Yang, M.
- Yu, H.
- Chromatin demethylation
- Chromatin regulator
- Corest
- Depression
- Fad
- Histone demethylase
- Host-virus interaction
- Lsd1
- Nuclear protein
- Nucleosome
- Oxidoreductase
- Oxidoreductase-repressor complex
- Phosphorylation
- Repressor
- Transcription
- Transcription regulation
- Tranylcypromine
