4dw6 | pdb_00004dw6
From Proteopedia
Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.
Template:ABSTRACT PUBMED 022738293
Function
[ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).[1][2]
About this Structure
4dw6 is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- ↑ Baulard AR, Betts JC, Engohang-Ndong J, Quan S, McAdam RA, Brennan PJ, Locht C, Besra GS. Activation of the pro-drug ethionamide is regulated in mycobacteria. J Biol Chem. 2000 Sep 8;275(36):28326-31. PMID:10869356 doi:10.1074/jbc.M003744200
- ↑ DeBarber AE, Mdluli K, Bosman M, Bekker LG, Barry CE 3rd. Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9677-82. PMID:10944230
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Mycobacterium tuberculosis
- Baulard, A R.
- Brodin, P.
- Christophe, T.
- Deprez, B.
- Desroses, M.
- Flipo, M.
- Hounsou, C.
- Jeon, H K.
- Lecat-Guillet, N.
- Lens, Z.
- Leroux, F.
- Locht, C.
- Villeret, V.
- Willand, N.
- Wintjens, R.
- Wohlkonig, A.
- Dna binding protein
- Inhibitor
- Tetr-family
- Transcription repressor-inhibitor complex
- Transcription-inhibitor complex
- Transcritptional regulatory repressor
