3i6r | pdb_00003i6r

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Template:STRUCTURE 3i6r

Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM74

Template:ABSTRACT PUBMED 19640844

Function

[PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

About this Structure

3i6r is a 1 chain structure with sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.

Reference

  1. Deng X, Gujjar R, El Mazouni F, Kaminsky W, Malmquist NA, Goldsmith EJ, Rathod PK, Phillips MA. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J Biol Chem. 2009 Sep 25;284(39):26999-7009. Epub 2009 Jul 28. PMID:19640844 doi:10.1074/jbc.M109.028589

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OCA

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