4j6g | pdb_00004j6g
From Proteopedia
CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX
Function
[TNF14_HUMAN] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. [TNF6B_HUMAN] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.[1]
About this Structure
4j6g is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC. Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure. 2011 Feb 9;19(2):162-71. PMID:21300286 doi:10.1016/j.str.2010.12.004
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Almo, S C.
- Bhosle, R C.
- Bonanno, J B.
- IFN, Atoms-to-Animals:.The Immune Function Network.
- Liu, W.
- NYSGRC, New York Structural Genomics Research Consortium.
- Nathenson, S G.
- Zhan, C.
- Atoms-to-animals: the immune function network
- Bind tnf receptor hvem and ltbr
- Cytokine
- Dcr3
- Ifn
- Immune system
- Jelly-roll fold
- Light
- Ltbr
- Membrane
- N-glycosylation
- New hvem
- New york structural genomics research consortium
- Nysgrc
- Protein structure initiative
- Psi-biology
- Secreted protein
- Structural genomic
- Tnf
- Tnf14
- Tnfr
