4ixh | pdb_00004ixh
From Proteopedia
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum
Function
[IMDH_CRYPV] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[1]
About this Structure
4ixh is a 4 chain structure with sequence from Cryptosporidium parvum. Full crystallographic information is available from OCA.
Reference
- ↑ Umejiego NN, Li C, Riera T, Hedstrom L, Striepen B. Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design. J Biol Chem. 2004 Sep 24;279(39):40320-7. Epub 2004 Jul 21. PMID:15269207 doi:10.1074/jbc.M407121200
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Cryptosporidium parvum
- IMP dehydrogenase
- Andesrson, W F.
- CSGID, Center for Structural Genomics of Infectious Diseases.
- Gu, M.
- Hedstrom, L.
- Joachimiak, A.
- Kavitha, M.
- Kim, Y.
- Makowska-Grzyska, M.
- Alpha-beta fold
- Center for structural genomics of infectious disease
- Csgid
- National institute of allergy and infectious disease
- Niaid
- Oxidoreductase
- Structural genomic
- Tim barrel
