3l4h | pdb_00003l4h

Function

[HECW1_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

About this Structure

3l4h is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Ubiquitin protein ligase

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