3kvv | pdb_00003kvv

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Template:STRUCTURE 3kvv

Trapping of an oxocarbenium ion intermediate in UP crystals

Template:ABSTRACT PUBMED 20364833

Function

[UDP_ECOLI] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

About this Structure

3kvv is a 6 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  1. Paul D, O'Leary SE, Rajashankar K, Bu W, Toms A, Settembre EC, Sanders JM, Begley TP, Ealick SE. Glycal formation in crystals of uridine phosphorylase. Biochemistry. 2010 Apr 27;49(16):3499-509. PMID:20364833 doi:10.1021/bi902073b

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OCA

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