3kyg | pdb_00003kyg

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Template:STRUCTURE 3kyg

Crystal structure of VCA0042 (L135R) complexed with c-di-GMP

Template:ABSTRACT PUBMED 20226196

Function

[Q9KNC3_VIBCH] May act as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Increasing levels of c-di-GMP lead to decreased motility (Potential). Binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP) with a dissociation constant of 170 nM in the presence of 10 mM KCl and with 100 mM in its absence.[HAMAP-Rule:MF_01457]

About this Structure

3kyg is a 2 chain structure with sequence from Vibrio cholerae. Full crystallographic information is available from OCA.

Reference

  1. Ko J, Ryu KS, Kim H, Shin JS, Lee JO, Cheong C, Choi BS. Structure of PP4397 reveals the molecular basis for different c-di-GMP binding modes by Pilz domain proteins. J Mol Biol. 2010 Apr 23;398(1):97-110. Epub 2010 Mar 10. PMID:20226196 doi:10.1016/j.jmb.2010.03.007

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