4hze | pdb_00004hze
From Proteopedia
Crystal structure of human Arginase-2 complexed with inhibitor 9
Template:ABSTRACT PUBMED 23472952
Function
[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
About this Structure
4hze is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Arginase
- Homo sapiens
- Andreoli, M.
- Beckett , P.
- Conway, B.
- Cousido-Siah, A.
- Golebiowski, A.
- Ji, M.
- Mahboubi, K.
- Mitschler, A.
- Podjarny, A.
- Ruiz, F X.
- Schroeter, H.
- Sheeler, R.
- Whitehouse, D L.
- Zandt, M C.Van.
- Zhang, M.
- Alpha/beta fold
- Arginine metabolism
- Hydrolase
- Hydrolase-hydrolase inhibitor complex
- Manganese
- Metalloenzyme
- Mitochondrion
