2ykd | pdb_00002ykd

From Proteopedia
Revision as of 23:18, 10 April 2013 by OCA (talk | contribs)
Jump to navigationJump to search

Template:STRUCTURE 2ykd

STRUCTURE OF THE MATRIX PROTEIN FROM HUMAN RESPIRATORY SYNCYTIAL VIRUS

Template:ABSTRACT PUBMED 21141948

Function

[MATRX_HRSVA] Has a crucial role in virus assembly and budding. The matrix interacts with the RNP complex and this association serves two functions: facilitate virion assembly and inhibit the viral transcriptase activity. Early in infection, M is localized to the nucleus and may inhibit host cell transcription. Later on, M can associate with lipid rafts supposely by interacting with the cytoskeleton and with the cytoplasmic tail of glycoprotein G. The binding of M to host membrane is stabilized by the surface expression of the viral glycoproteins. These interactions may allow virus formation by mediating association of the nucleocapsid with the nascent envelop.[1]

About this Structure

2ykd is a 1 chain structure with sequence from Human respiratory syncytial virus. Full crystallographic information is available from OCA.

Reference

  1. McPhee HK, Carlisle JL, Beeby A, Money VA, Watson SM, Yeo RP, Sanderson JM. Influence of lipids on the interfacial disposition of respiratory syncytical virus matrix protein. Langmuir. 2011 Jan 4;27(1):304-11. Epub 2010 Dec 9. PMID:21141948 doi:10.1021/la104041n
  1. ↑ Ghildyal R, Mills J, Murray M, Vardaxis N, Meanger J. Respiratory syncytial virus matrix protein associates with nucleocapsids in infected cells. J Gen Virol. 2002 Apr;83(Pt 4):753-7. PMID:11907323

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2ykd&oldid=1774487"