3m5b | pdb_00003m5b
From Proteopedia
Crystal structure of the BTB domain from FAZF/ZBTB32
Function
[ZBT32_HUMAN] DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).[1]
About this Structure
3m5b is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Stogios PJ, Cuesta-Seijo JA, Chen L, Pomroy NC, Prive GG. Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. J Mol Biol. 2010 Jul 30;400(5):983-97. Epub 2010 May 21. PMID:20493880 doi:10.1016/j.jmb.2010.05.028
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Pomroy, N C.
- Prive, G G.
- Stogios, P J.
- Alpha/beta protein
- Btb domain
- Btb/poz domain
- Dna binding protein
- Dna-binding
- Fancc-interacting protein
- Fanconi anemia zinc finger protein
- Faxf
- Fazf
- Metal-binding
- Nucleus
- Poz domain
- Protein-protein interaction domain
- Repressor
- Rog
- Testis zinc finger protein
- Transcription
- Transcription regulation
- Transcription regulator
- Tzfp
- Zbtb32
- Zinc finger and btb domain-containing protein 32
- Zinc-finger
- Zinc-finger protein
- Znf538
