3nau | pdb_00003nau

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Template:STRUCTURE 3nau

Crystal structure of ZHX2 HD2 (zinc-fingers and homeoboxes protein 2, homeodomain 2)

Template:ABSTRACT PUBMED 20509910

Function

[ZHX2_HUMAN] Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.[1]

About this Structure

3nau is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Bird LE, Ren J, Nettleship JE, Folkers GE, Owens RJ, Stammers DK. Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains. BMC Struct Biol. 2010 May 28;10:13. PMID:20509910 doi:10.1186/1472-6807-10-13
  1. ↑ Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. Biochem J. 2003 Aug 1;373(Pt 3):747-57. PMID:12741956 doi:10.1042/BJ20030171

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