3n7o | pdb_00003n7o

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Revision as of 21:15, 17 April 2013 by OCA (talk | contribs) (Protected "3n7o" [edit=sysop:move=sysop])
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Template:STRUCTURE 3n7o

X-ray structure of human chymase in complex with small molecule inhibitor.

Template:ABSTRACT PUBMED 20599788

Function

[CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

About this Structure

3n7o is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Kervinen J, Crysler C, Bayoumy S, Abad MC, Spurlino J, Deckman I, Greco MN, Maryanoff BE, de Garavilla L. Potency variation of small-molecule chymase inhibitors across species. Biochem Pharmacol. 2010 Oct 1;80(7):1033-41. Epub 2010 Jun 23. PMID:20599788 doi:10.1016/j.bcp.2010.06.014

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