3nm9 | pdb_00003nm9
From Proteopedia
HMGD(M13A)-DNA complex
Function
[HMGD_DROME] Binds preferentially single-stranded DNA and unwinds double stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1.[1] [2] [3]
About this Structure
3nm9 is a 16 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
- Churchill ME, Klass J, Zoetewey DL. Structural Analysis of HMGD-DNA Complexes Reveals Influence of Intercalation on Sequence Selectivity and DNA Bending. J Mol Biol. 2010 Aug 25. PMID:20800069 doi:10.1016/j.jmb.2010.08.031
- ↑ Wagner CR, Hamana K, Elgin SC. A high-mobility-group protein and its cDNAs from Drosophila melanogaster. Mol Cell Biol. 1992 May;12(5):1915-23. PMID:1373803
- ↑ Ner SS, Travers AA. HMG-D, the Drosophila melanogaster homologue of HMG 1 protein, is associated with early embryonic chromatin in the absence of histone H1. EMBO J. 1994 Apr 15;13(8):1817-22. PMID:8168480
- ↑ Churchill ME, Jones DN, Glaser T, Hefner H, Searles MA, Travers AA. HMG-D is an architecture-specific protein that preferentially binds to DNA containing the dinucleotide TG. EMBO J. 1995 Mar 15;14(6):1264-75. PMID:7720717
